Bill Murray .... Dr. Peter Venkman
Dan Aykroyd .... Dr. Raymond Stantz
Sigourney Weaver .... Dana Barrett
Harold Ramis .... Dr. Egon Spengler
Rick Moranis .... Louis Tully/Vinz Clortho, the Key Master
Annie Potts .... Janine Melnitz
William Atherton .... Walter Peck
Ernie Hudson .... Winston Zeddemore
David Margulies .... Mayor Lenny
Steven Tash .... Male Student
Jennifer Runyon .... Female Student Jennifer
Slavitza Jovan .... Gozer
Michael Ensign .... Hotel Manager
Alice Drummond .... Librarian Alice
Jordan Charney .... Dean Yeager
Timothy Carhart .... Violinist
John Rothman .... Library Adminstrator Roger Delacrow
Tom McDermott .... Archbishop Mike
Roger Grimsby .... Himself
Larry King .... Himself
Joe Franklin .... Himself
Casey Kasem .... Himself
John Ring .... Fire Commissioner John
Norman Matlock .... Police Commissioner
Joe Cirillo .... Police Captain
Joe Schmieg .... Police Seargeant
Reginald VelJohnson .... Jail Guard (as Reggie VelJohnson)
Rhoda Gemignani .... Real Estate Woman
Murray Rubin .... Man at Elevator
Larry Dilg .... Con Edison Man
Danny Stone .... Coachman
Patty Dworkin .... Woman at Party
Jean Kasem .... Tall Woman at Party
Lenny Del Genio .... Doorman
Frances E. Nealy .... Chambermaid
Sam Moses .... Hot Dog Vendor
Christopher Wynkoop .... T.V. Reporter
Winston May .... Businessman in Cab
Tommy Hollis .... Mayor's Aide
Eda Reiss Merin .... Louis's Neighbor
Ric Mancini .... Policeman at Apartment (as Rick Mancini)
Kathryn Janssen .... Mrs. Van Hoffman
Stanley Grover .... Reporter
Carol Ann Henry .... Reporter
James Hardie .... Reporter (as James Hardy)
Frances Turner .... Reporter
Nancy Kelly .... Reporter
Paul Trafas .... Ted Fleming
Cheryl Birchenfield .... Annette Fleming
Ruth Oliver .... Library Ghost
Kymberly Herrin .... Dream Ghost (as Kym Herrin)
Matteo Cafiso .... Boy at Hot Dog Stand (uncredited)
Paddi Edwards .... Gozer (voice) (uncredited)
Deborah Gibson .... Birthday Girl in Tavern on the Green (uncredited)
Joseph Marzano .... Man in Taxi (uncredited)
Joe Medjuck .... Man at Library (uncredited)
Frank Patton .... City Hall Cop (uncredited)
Harrison Ray .... Terror Dog (uncredited)
Ivan Reitman .... Zuul/Slimer (voice) (uncredited)

Peter Venkman, Ray Stantz, and Egon Spengler are three scientists at Columbia University in New York City. When their grant expires, the guys are fired and they go into business as a ghost extermination company called "Ghostbusters". Their first customer is orchestra cello player Dana Barrett, who was scared out of her apartment on the 22nd floor of a high rise apartment building on Central Park West. It seems that Dana's neighbor, Louis Tully, is also being affected by the strange happenings in the apartment building. Armed with proton guns, the Ghostbusters become wildly popular, and they are joined by Winston Zeddmore, who is looking for a job with good pay. Overzealous Environmental Protection Agency (EPA) agent Walter Peck thinks the Ghostbusters are frauds, and he has the Ghostbusters put in jail. Peck is forced to believe the Ghostbusters when New York City is put under siege by an ancient Sumerian God named Gozer the Gozerian, who is channeled through the apartment building that Dana and Louis live in, and the mayor has no choice but to let the Ghostbusters out of jail to face Gozer.

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